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The key risks across both compounds include: Gastrointestinal adverse events (nausea, vomiting, diarrhoea), most pronounced during dose escalation Potential for gallbladder disease, consistent with rapid weight reduction Retatrutide-specific: dysesthesia and elevated resting heart rate [3] Both compounds: risk of hypoglycaemia when used in combination with insulin or sulphonylureas in diabetic models All compounds available through Sempica are strictly for research use by qualified professionals